Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Potential occupational risks for neurodegenerative diseases.

Authors
Park-RM; Schulte-PA; Bowman-JD; Walker-JT; Bondy-SC; Yost-MG; Touchstone-JA; Dosemeci-M
Source
Am J Ind Med 2005 Jul; 48(1):63-77
NIOSHTIC No.
20027134
Abstract
Associations between occupations and neurodegenerative diseases (NDD) may be discernable in death certificate data. Hypotheses generated from 1982 to 1991 study were tested in data from 22 states for the years 1992-1998. Specific occupations and exposures to pesticides, solvents, oxidative stressors, magnetic fields, and welding fumes were evaluated. About one third (26/87) of the occupations hypothesized with neurodegenerative associations had statistically significant elevated mortality odds ratios (MOR) for the same outcome. Occupations with the largest MORs were (a) for presenile dementia (PSD) - dentists, graders/sorters (non-agricultural), and clergy; (b) for Alzheimer's disease (AD) - bank tellers, clergy, aircraft mechanics, and hairdressers; (c) for Parkinson's disease (PD) - biological scientists, clergy, religious workers, and post-secondary teachers; and (d) for motor neuron disease (MND) - veterinarians, hairdressers, and graders and sorters (non-agricultural). Teachers had significantly elevated MORs for all four diseases, and hairdressers for three of the four. Non-horticultural farmers below age 65 had elevated PD (MOR = 2.23, 95 per cent CI = 1.47-3.26), PSD (MOR = 2.22, 95 per cent CI = 1.10-4.05), and AD (MOR = 1.76, 95 per cent CI = 1.04-2.81). Sixty hertz magnetic fields exhibited significant exposure-response for AD and, below age 65, for PD (MOR = 1.87, 95 per cent CI = 1.14-2.98) and MND (MOR = 1.63, 95 per cent CI = 1.10-2.39). Welding had elevated PD mortality below age 65 (MOR = 1.77, 95 per cent CI = 1.08-2.75). Support was observed for hypothesized excess neurodegenerative disease associated with a variety of occupations, 60 Hz magnetic fields and welding.
Keywords
Occupational-diseases; Neurological-diseases; Neuromotor-disorders; Brain-disorders; Magnetic-fields; Pesticides; Welding; Teaching; Hairdressers; Solvents; Mortality-data; Oxidative-processes; Farmers; Author Keywords: Alzheimers disease; hairdresser; motor neuron disease; magnetic field; Parkinsons disease; pesticide; welding
Contact
National Institute for Occupational Safety and Health, Education and Information Division, Mail Stop C-15, 4676 Columbia Parkway, Cincinnati, OH 45226-1998
CODEN
AJIMD8
CAS No.
71-43-2
Publication Date
20050701
Document Type
Journal Article
Email Address
rhp9@cdc.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0271-3586
NIOSH Division
EID; DART; DSHEFS
Source Name
American Journal of Industrial Medicine
State
CA; MD; OH; WA
TOP