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Is NF-kappaB a culprit in type 2 diabetes?

Authors
Chen-F
Source
Biochem Biophys Res Commun 2005 Jun; 332(1):1-3
NIOSHTIC No.
20027080
Abstract
It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. Earlier studies indicated that IKKbeta was the key for the development of insulin resistance. However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles in insulin resistance. New data suggest that NF-kappaB and NF-kappaB-regulated cytokines are crucial for the diabetogenesis.
Keywords
Endocrine-system; Endocrine-function; Endocrine-system-disorders; Gene-mutation; Genetic-factors
CODEN
BBRCA9
Publication Date
20050624
Document Type
Journal Article
Email Address
fchen@cdc.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0006-291X
NIOSH Division
HELD
Source Name
Biochemical and Biophysical Research Communications
State
WV
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