Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Cutting fluid formulations influence the dermal disposition of linear alkylbenzene sulfonate (LAS).

Authors
Baynes-RE; Brooks-JD; Barlow-BM; Riviere-JE
Source
Toxicologist 2002 Mar; 66(1-S):163
NIOSHTIC No.
20027028
Abstract
Linear alkylbenzene sulfonate (LAS) is often added as a surfactant to cutting fluid formulations to enhance the performance of metal machining operations. Unfortunately, LAS and other cutting fluid additives can cause contact dermatitis in workers in the metalworking industry. The purpose of this study was to assess membrane absorption and deposition of 14C-LAS when topically applied to inert membranes (silastic membranes) and porcine skin in in vitro flow-through diffusion cell system as mineral oil or polyethylene glycol (PEG) mixtures. 14C-LAS mixtures were formulated with 3 other additives; namely, 0 or 2% triazine (TRI), 0 or 5% triethanolamine (TRE), and 0 or 5% sulfurized ricinoleic acid (SRA) as follows: TRI, TEA, SRA, TRI+TEA, TRI+SRA, TEA+SRA, TRI+TEA+SRA. In silastic membranes, LAS absorption ranged from 0.09 - 0.19% dose, and there were no differences between corresponding mineral oil and PEG mixtures. Membrane levels were greatest with TRI only in mineral oil and PEG mixtures. In porcine skin, 14CLAS absorption ranged from 0.06 - 0.32% dose, and there were significant differences between several mineral oil and PEG mixtures. LAS penetration into stratum coneum (SC) was often greater in mineral oil than in PEG mixtures. Surprisingly, LAS absorption was significantly greater in pig skin than in silastic membranes for PEG mixtures containing TRI+ TEA. These observations suggest that although very little LAS is absorbed, cutting fluid components can alter LAS deposition into the SC and skin. Furthermore, chemical-biological interactions in viable skin with synergism with a biocide (TRI) and an amine (TEA) may be important determinants for LAS disposition in skin.
Keywords
Cutting-oils; Oil-mists; Dermatosis; Detergent-enzymes; Skin-absorption; Skin-exposure; Skin-irritants; In-vitro-studies
Contact
Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP), College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606
CAS No.
102-71-6
Publication Date
20020301
Document Type
Abstract
Funding Amount
875919
Funding Type
Grant
Fiscal Year
2002
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003669
ISSN
1096-6080
Priority Area
Disease and Injury: Allergic and Irritant Dermatitis
Source Name
The Toxicologist. Society of Toxicology 41st Annual Meeting and ToxExpo, March 17-21, 2002, Nashville, Tennessee
State
NC; TN
Performing Organization
North Carolina State University, Raleigh, NC
TOP