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DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.

Authors
Durkin-ME; Avner-MR; Huh-CG; Yuan-BZ; Thorgeirsson-SS; Popescu-NC
Source
FEBS Lett 2005 Feb; 579(5):1191-1196
NIOSHTIC No.
20026874
Abstract
DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions.
Keywords
Proteins; Cell-growth; Tumorigenesis; Laboratory-animals; Animals; Animal-studies; Histology; Tumors; Tumorigens; Liver-cancer; Pulmonary-system-disorders; Respiratory-system-disorders; Teratogenesis; Teratology; Central-nervous-system-disorders; Cardiovascular-system-disorders
Contact
Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
CODEN
FEBLAL
Publication Date
20050214
Document Type
Journal Article
Email Address
marian_durkin@nih.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0014-5793
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
Federation of European Biochemical Societies Letters
State
WV; MD
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