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A novel system coefficient approach for quantitative assessment of dermal absorption from chemical mixtures by using the membrane-coated fiber technique.

Authors
Xia-XR; Baynes-RE; Monteiro-Riviere-NA; Riviere-JE
Source
Toxicologist 2005 Mar; 84(Suppl 1):450
NIOSHTIC No.
20026511
Abstract
Chemical exposure in most environmental and occupational settings involves complicated chemical mixtures, not individual chemicals. However, current health risk assessment of dermal absorption is based on permeation data for individual chemicals due to lack of available quantitative methods or experimental data from chemical mixtures. In the system coefficient approach, a set of solute descriptors, represents the molecular interaction strengths of a chemical of interest, while a set of system coefficients, [r, s, a, b, v], represents those of the skin/medium system. The permeation coefficient or partition coefficient (logK) is correlated with the system coefficients and the solute descriptors via Abraham's linear free energy relationship. The major components of the mixture determine the system coefficients. When the major components change in composition or proportion, the system coefficients will be changed. When 25% of ethanol was added to the water solution of the 32 calibration compounds, the system coefficient changes of the polyacrylate/water system were [-0.12, 0.17, 0.23, 0.33, -0.42], respectively. When 1% of sodium lauryl sulfate was added to the water solution, the system coefficient changes were [-0.41, 0.34, 0.23, 0.74, -1.53], respectively. In practical risk assessments, the changes in system coefficients can be treated as sufficiently similar mixtures. If the system coefficients of the mixture of concern and the system coefficients of the sufficiently similar mixtures are determined, the permeability or partition coefficient of any chemical can be obtained by using the system coefficient approach.
Keywords
Quantitative-analysis; Absorption-rates; Chemical-analysis; Occupational-exposure; Environmental-exposure; Chemical-reactions; Chemical-composition; Risk-factors; Risk-analysis; Synergism
Publication Date
20050301
Document Type
Abstract
Funding Amount
746428
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007555; Grant-Number-R01-OH-003369
ISSN
1096-6080
Priority Area
Work Environment and Workforce: Mixed Exposures
Source Name
The Toxicologist. Society of Toxicology 44th Annual Meeting and ToxExpo, March 6-10, 2005, New Orleans, Louisiana
State
NC
Performing Organization
North Carolina State University, Raleigh, North Carolina
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