Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Involvement of oxidative stress in potentiation of noise induced hearing loss (NIHL) by chemical contaminants.

Authors
Fechter-LD; Pouyatos-B; Gearhart-CA
Source
Toxicologist 2005 Mar; 84(Suppl 1):10
NIOSHTIC No.
20026425
Abstract
Permissible workplace exposure limits for noise and for chemical contaminants generally rely upon laboratory and epidemiological investigations that entail exposure to the single agent of interest. However, a growing body of research shows that a variety of chemical contaminants, including those that have no effect upon auditory function, can potentiate noise induced hearing loss. Such potentiation is particularly noteworthy when it occurs for low intensity noise exposures that approach the permissible human noise exposure standards.We predict that chemicals able to impair intrinsic antioxidant mechanisms potentiate NIHL since reactive oxygen species may be generated even at low noise levels. Combined exposure of rats to hydrogen cyanide and mild noise yields significant auditory impairment while at neither agent given alone resulted in hearing loss. Using antioxidant drug treatments to protect auditory function and pro-oxidant drugs to promote oxidative stress we find support for our hypothesis that oxidative stress does play a role in potentiation of noise induced hearing loss by hydrogen cyanide.
Keywords
Noise-induced-hearing-loss; Chemical-reactions; Ototoxicity; Hearing-loss; Noise-exposure; Free-radical-generation; Free-radicals; Tissue-disorders; Synergism
CAS No.
74-90-8
Publication Date
20050301
Document Type
Abstract
Funding Amount
561752
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003481
ISSN
1096-6080
Priority Area
Disease and Injury: Hearing Loss
Source Name
The Toxicologist. Society of Toxicology 44th Annual Meeting and ToxExpo, March 6-10, 2005, New Orleans, Louisiana
State
CA; OK
Performing Organization
University of Oklahoma, Health Sciences Center, Oklahoma Center for Toxicology, Oklahoma City, Oklahoma
TOP