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Longitudinal changes in lung function and airflow limitation in pulp mill workers reporting ozone gassing incidents.

Authors
Mehta-AJ; Henneberger-PK; Toren-K; Olin-AC
Source
Am J Respir Crit Care Med 2004 Apr; 169(7)(Abstracts):A46
NIOSHTIC No.
20026046
Abstract
We investigated whether occupational exposure to ozone gassings in pulp mills was associated with increased airflow limitation and decline in lung function. We used both cross-sectional and longitudinal data in our analysis. Bleachery workers potentially exposed to ozone (n=179) from three Swedish pulp mills were studied, as was a comparison group of paper mill workers not exposed to ozone (n=62) from two of the three pulp mills. Initial and follow-up surveys took place in 1996 and 1999, respectively. Participants underwent spirometry testing and provided answers to a questionnaire regarding history of accidental exposure to ozone. gassings. Several- analyses suggested that bleachery workers with a history of four or more ozone gassings (n=25) had obstructive changes when compared to paper mill workers. The group of workers with at least 4 ozone gassings had lower forced expiratory volume in one second (FEV1) and lower ratio of FEV1 over forced vital capacity (FEV1/FVC) in 1999, controlling for potential confounders (age, gender, height, weight, smoking) by linear regression analyses (-0.219 L, p=0.06; -2.69%, p=0.05, respectively). In another regression model controlling for potential confounders, this exposed group also had an additional 17 ml longitudinal decline in FEV1 (L/yr) between 1996 and 1999 in comparison to paper mill workers, although this difference was not statistically significant (p=0.21). In 1999, workers with at least 4 gassings were also more likely to have airflow limitation (i.e., FEV1/FVC < 70%), although the association was not statistically significant at the p<0.05 level (prevalence ratio: 3.72, 95% CI: 0.66-20.94, p=0.14). These findings suggest that obstructive changes in lung function among pulp mill workers are associated with multiple ozone gassings.
Keywords
Pulmonary-function; Humans; Lung-function; Pulmonary-system-disorders; Pulmonary-disorders; Respiratory-system-disorders; Spirometry; Paper-mills; Paper-milling; Paper-manufacturing-industry; Pulp-industry; Epidemiology; Statistical-analysis; Demographic-characteristics
CODEN
AJCMED
CAS No.
10028-15-6
Publication Date
20040401
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
zuz9@cdc.gov
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
7
ISSN
1073-449X
NIOSH Division
DRDS
Source Name
American Journal of Respiratory and Critical Care Medicine
State
WV
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