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Mortality patterns in Indiana workers exposed to polychlorinated biphenyls (PCBs).

Authors
Ruder-AM; Hein-MJ; Nilsen-N; Waters-MA; Laber-P; Davis-King-K; Prince-MM; Whelan-E
Source
Am J Epidemiol 2004 Jun; 159(11)(Suppl):S20
NIOSHTIC No.
20026029
Abstract
Background: Mortality was updated through 1998 for 3,588 workers exposed to polychlorinated biphenyls (PCBs) between 1957 and 1986 at a capacitor manufacturing plant, to evaluate excess melanoma and brain cancer, originally seen in this cohort, and rectal, liver, biliary tract, and gall bladder cancer, and non-Hodgkins lymphoma, observed in other PCB studies. Methods: Standardized mortality ratios (SMR) and 95% confidence intervals (CI) used Indiana state (shown) and U. S. rates. A new job-exposure matrix calculated estimated cumulative exposure. Results: Overall mortality was reduced (547 deaths, SMR 0.81, CI 0.75, 0.88). Melanoma was significantly elevated (9 deaths, SMR 2.43, CI 1.11,4.60); brain cancer (12 deaths, SMR 1.91, CI 0.98, 3.33) and non-Hodgkins lymphoma (9 deaths, SMR 1.23, CI 0.56, 2.33) were elevated. Other cancers of a priori interest were not in excess. When the cohort was stratified by quartiles of estimated cumulative exposure, melanoma was in excess in the lowest quartile (4 deaths, SMR 4.09, CI 1.12, 10.5), with a trend (p = 0.014) of decreasing SMR with increasing exposure. Brain cancer was in excess in the highest quartile (5 deaths, SMR 3.55, CI US, 8.28) but there was no dose response trend. Among 2,789 individuals who worked at least 90 days, both melanoma (8 deaths, SMR 2.66, CI 1.15,24) and brain cancer (II deaths, SMR 2.12, CI 1.06, 80) were in excess. Conclusion: These findings reinforce those of the original study. For both melanoma and brain cancer, mortality and estimated cumulative exposure do not fulfill dose-response relationships.
Keywords
Epidemiology; Statistical-analysis; Mortality-rates; Mortality-data; Mortality-surveys; Brain-tumors; Skin-cancer; Skin-disorders; Skin-diseases; Central-nervous-system-disorders; Bladder-cancer; Bladder-disorders; Bladder-disease; Gastrointestinal-system-disorders; Gastrointestinal-system; Liver-cancer; Liver-disorders; Liver-tumors; Polychlorinated-biphenyls
CODEN
AJEPAS
Publication Date
20040601
Document Type
Abstract
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
11
ISSN
0002-9262
NIOSH Division
DSHEFS
Source Name
American Journal of Epidemiology. Society for Epidemiologic Research (SER). Abstracts of the 37th Annual Meeting, Salt Lake City, Utah, June 15-18, 2004
State
OH
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