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Proposed criteria for mixed-dust pneumoconiosis: definition, descriptions, and guidelines for pathologic diagnosis and clinical correlation.

Authors
Honma-K; Abraham-JL; Chiyotani-K; De Vuyst-P; Dumortier-P; Gibbs-AR; Green-FH; Hosoda-Y; Iwai-K; Williams-WJ; Kohyama-N; Ostiguy-G; Roggli-VL; Shida-H; Taguchi-O; Vallyathan-V
Source
Hum Pathol 2004 Dec; 35(12):1515-1523
NIOSHTIC No.
20025990
Abstract
We defined mixed-dust pneumoconiosis (MDP) pathologically as a pneumoconiosis showing dust macules or mixed-dust fibrotic nodules (MDF), with or without silicotic nodules (SN), in an individual with a history of exposure to mixed dust. We defined the latter arbitrarily as a mixture of crystalline silica and nonfibrous silicates. According to our definition of MDP, therefore, MDF should outnumber SN in the lung to make a pathologic diagnosis of MDP. In the absence of confirmation of exposure, mineralogic analyses can be used to support the pathologic diagnosis. The clinical diagnosis of MDP requires the exclusion of other well-defined pneumoconioses, including asbestosis, coal workers' pneumoconiosis, silicosis, hematite miners' pneumoconiosis, welders' pneumoconiosis, berylliosis, hard metal disease, silicate pneumoconiosis, diatomaceous earth pneumoconiosis, carborundum pneumoconiosis, and corundum pneumoconiosis. Typical occupations associated with the diagnosis of MDP include metal miners, quarry workers, foundry workers, pottery and ceramics workers, and stonemasons. Irregular opacities are the major radiographic findings in MDP (ILO 1980), in contrast to silicosis, in which small rounded opacities predominate. Clinical symptoms of MDP are nonspecific. MDP must be distinguished from a variety of nonoccupational interstitial pulmonary disorders.
Keywords
Pneumoconiosis; Dusts; Exposure-levels; Silicates; Silica-dusts; Pathology; Asbestosis; Coal-dust; Coal-workers-pneumoconiosis; Occupational-exposure; Silicosis; Lung-disorders; Pulmonary-system-disorders; Respiratory-system-disorders
CODEN
HPCQA4
CAS No.
14808-60-7
Publication Date
20041201
Document Type
Journal Article
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
12
ISSN
0046-8177
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
Human Pathology
State
WV; NC
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