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Molecular mechanisms of arsenic carcinogenesis.

Authors
Huang-C; Ke-Q; Costa-M; Shi-X
Source
Mol Cell Biochem 2004 Jan; 255(1-2):57-66
NIOSHTIC No.
20025983
Abstract
Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been associated with increased cancer incidence. Although the exact mechanisms remain to be investigated, numerous carcinogenic pathways have been proposed. Potential carcinogenic actions for arsenic include oxidative stress, genotoxic damage, DNA repair inhibition, epigenetic events, and activation of certain signal transduction pathways leading to abberrant gene expression. In this article, we summarize current knowledge on the molecular mechanisms of arsenic carcinogenesis with an emphasis on ROS and signal transduction pathways.
Keywords
Arsenic-compounds; Carcinogenesis; Carcinogenicity; Carcinogens; Metalloids; Cancer; Cancer-rates; Exposure-levels; Genotoxic-effects; Genes
Contact
C. Huang, Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
CODEN
MCBIB8
CAS No.
7440-38-2
Publication Date
20040101
Document Type
Journal Article
Email Address
chuanshu@env.med.nyu.edu
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0300-8177
NIOSH Division
HELD
Source Name
Molecular and Cellular Biochemistry
State
WV; NY
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