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Endogenous inhibitors of nuclear factor-kB, an opportunity for cancer control.

Authors
Chen-F
Source
Cancer Res 2004 Nov; 64(22):8135-8138
NIOSHTIC No.
20025977
Abstract
Excessive and prolonged activation of nuclear factor-B (NF-B) has been linked to numerous human diseases, especially cancer, because of the elevated expression of genes encoding antiapoptotic proteins, cytokines, chemokines, cell adhesion molecules, and so on. Eukaryotic cells have developed multiple mechanisms to keep this ubiquitous transcription factor in check. In addition to the inhibitor of B family proteins, a number of endogenous molecules that negatively regulate the activation or activity of NF-B have been identified. These molecules include A20, CYLD, cyPG15-deoxy-12,14-prostaglandin J2, Foxj1, Twist proteins, and -arrestins. The extended list of these endogenous inhibitors of NF-B may provide new opportunities for the development of novel strategies for the intervention of malignant transformation. The question to be asked is how NF-B is sustained activated in a number of cancers in which so many antagonists are surrounded.
Keywords
Cancer; Diseases; Proteins; Carcinogenesis; Carcinogenicity; Carcinogens; Genetic-factors; Genetic-disorders; Genetics; Genes
Contact
Fei Chen, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
CNREA8
Publication Date
20041115
Document Type
Journal Article
Email Address
LFD3@cdc.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
22
ISSN
0008-5472
NIOSH Division
HELD
Source Name
Cancer Research
State
WV
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