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Hexavalent chromium and lung cancer in the chromate industry: a quantitative risk assessment.

Authors
Park-RM; Bena-JF; Stayner-LT; Smith-RJ; Gibb-HJ; Lees-PSJ
Source
Risk Anal 2004 Oct; 24(5):1099-1108
NIOSHTIC No.
20025956
Abstract
The purpose of this investigation was to estimate excess lifetime risk of lung cancer death resulting from occupational exposure to hexavalent-chromium-containing dusts and mists. The mortality experience in a previously studied cohort of 2,357 chromate chemical production workers with 122 lung cancer deaths was analyzed with Poisson regression methods. Extensive records of air samples evaluated for water-soluble total hexavalent chromium were available for the entire employment history of this cohort. Six different models of exposure-response for hexavalent chromium were evaluated by comparing deviances and inspection of cubic splines. Smoking (pack-years) imputed from cigarette use at hire was included in the model. Lifetime risks of lung cancer death from exposure to hexavalent chromium (assuming up to 45 years of exposure) were estimated using an actuarial calculation that accounts for competing causes of death. A linear relative rate model gave a good and readily interpretable fit to the data. The estimated rate ratio for 1 mg/m3-yr of cumulative exposure to hexavalent chromium (as CrO3), with a lag of five years, was RR= 2.44 (95% CI = 1.543.83). The excess lifetime risk of lung cancer death from exposure to hexavalent chromium at the current OSHA permissible exposure limit (PEL) (0.10 mg/m3) was estimated to be 255 per 1,000 (95% CI: 109416). This estimate is comparable to previous estimates by U.S. EPA, California EPA, and OSHA using different occupational data. Our analysis predicts that current occupational standards for hexavalent chromium permit a lifetime excess risk of dying of lung cancer that exceeds 1 in 10, which is consistent with previous risk assessments.
Keywords
Lung-cancer; Lung-disorders; Lung-function; Hexavalent-chromium-compounds; Chemical-indicators; Chemical-industry-workers; Poisons; Racial-factors; Sex-factors; Risk-analysis; Demographic-characteristics; Humans; Epidemiology; Statistical-analysis
Contact
Robert M. Park, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-15, Cincinnati, OH 45226-1998
CODEN
RIANDF
CAS No.
7440-47-3
Publication Date
20041001
Document Type
Journal Article
Email Address
rhp9@cdc.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0272-4332
NIOSH Division
EID
Source Name
Risk Analysis
State
OH
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