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Microsomal epoxide hydrolase, endotoxin, and lung function decline in cotton textile workers.

Authors
Hang-J; Zhou-W; Wang-X; Zhang-H; Sun-B; Dai-H; Su-L; Christiani-DC
Source
Am J Respir Crit Care Med 2005 Jan; 171(2):165-170
NIOSHTIC No.
20025945
Abstract
Occupational exposure to endotoxin in organic dust may induce lung function decline. Microsomal epoxide hydrolase (mEH) detoxifies reactive oxygen species generated by endotoxin exposure, and polymorphisms of the mEH gene are associated with altered enzyme activity. We investigated the associations between mEH polymorphisms, endotoxin exposure, and lung function decline in a 20-year prospective study of 265 workers exposed to endotoxin and 234 control subjects. mEH Tyr113His and His139Arg polymorphisms were genotyped by the 5' nuclease assay, and data were analyzed using multivariate linear regression models, adjusting for important covariates. Overall, the annual decline rate of FEV1 was 29.47 ml during the 20-year follow-up. Endotoxin exposure was associated with faster lung function decline among genotypes associated with slower enzyme activity: estimates (SE) of annual FEV1 decline rates for endotoxin exposure were -2.33 (2.07), -2.81 (1.66), and -6.73 (2.83) ml for Tyr/Tyr, Tyr/His, and His/His genotype groups, respectively, for the Tyr113His polymorphism; and -1.82 (2.58) and -4.27 (1.33) ml for Arg/Arg + His/Arg and His/His genotypes, respectively, for the His139Arg polymorphism. We conclude that mEH polymorphisms modify the association between occupational endotoxin exposure and longitudinal lung function decline.
Keywords
Organic-dust; Mineral-dust; Pulmonary-system-disorders; Chronic-obstructive-pulmonary-disease; Free-radicals; Respiratory-system-disorders
Contact
David C. Christiani, M.D., M.P.H., Harvard School of Public Health, 665 Huntington Avenue, Building I-1407, Boston, MA 02115
CODEN
AJCMED
Publication Date
20050115
Document Type
Journal Article
Email Address
dchristi@hsph.harvard.edu
Funding Amount
1348724
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002421
Issue of Publication
2
ISSN
1073-449X
Source Name
American Journal Respiratory and Critical Care Medicine
State
MA
Performing Organization
Harvard University
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