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Biocidal activity of formaldehyde and nonformaldehyde biocides toward Mycobacterium immunogenum and Pseudomonas fluorescens in pure and mixed suspensions in synthetic metalworking fluid and saline.

Authors
Selvaraju-SB; Khan-IUH; Yadav-JS
Source
Appl Environ Microbiol 2005 Jan; 71(1):542-546
NIOSHTIC No.
20025937
Abstract
The microbicidal activity of four different biocides was studied in synthetic metalworking fluid (MWF) against Mycobacterium immunogenum, a suspected causative agent for hypersensitivity pneumonitis, and Pseudomonas fluorescens, a representative for the predominant gram-negative bacterial contaminants of MWF. The results indicated that M. immunogenum is more resistant than P. fluorescens to the tested formaldehyde-releasing biocides (Grotan and Bioban), isothiazolone (Kathon), and phenolic biocide (Preventol). Kathon was effective against mycobacteria at lower concentrations than the other three test biocides in MWF. In general, there was a marked increase in biocidal resistance of both the test organisms when present in MWF matrix compared to saline. Increased resistance of the two test organisms to biocides was observed when they were in a mixed suspension (1:1 ratio). The results indicate the protective effect of the MWF matrix against the action of commonly used biocides on the MWF-colonizing microbial species of occupational health significance, including mycobacteria.
Keywords
Microorganisms; Metalworking-fluids; Metalworking-industry; Metalworking; Pulmonary-system-disorders; Respiratory-system-disorders; Bacteria; Bacterial-disease; Bacterial-infections; Viral-diseases; Viral-infections
Contact
Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267-0056
CODEN
AEMIDF
Publication Date
20050101
Document Type
Journal Article
Email Address
Jagjit.Yadav@uc.edu
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007364
Issue of Publication
1
ISSN
0099-2240
Source Name
Applied and Environmental Microbiology
State
OH
Performing Organization
University of Cincinnati
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