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Chemokine receptor CCR2 involvement in skeletal muscle regeneration.

Authors
Warren-GL; Hulderman-T; Mishra-D; Gao-X; Millecchia-L; O'Farrell-L; Kuziel-WA; Simeonova-PP
Source
FASEB J 2005 Mar; 19(3):413-415
NIOSHTIC No.
20025892
Abstract
Chemokines, signaling through the CCR2 receptor, are highly expressed in injured skeletal muscle. Their target specificity depends on the cellular expression of the specific receptors. Here we demonstrate that, in freeze-injured muscle, CCR2 co-localized with Mac-3, a marker of activated macrophages as well as with myogenin, a marker of activated muscle precursor cells. The degeneration/regeneration process in skeletal muscle of CCR2-/- and wild-type mice was not significantly different at day 3. However in contrast to the regenerated muscle of the wild-type mice, the muscle from CCR2-/- mice was characterized by impaired regeneration, inflammation, and fibrotic response at day 14, increased fat infiltration, fibrosis, and calcification at day 21, and impaired strength recovery until at least 28 days post-injury. Consistently, the increased expression of Mac-1 and TNF-a was prolonged in the injured muscle of CCR2-/- mice. The expression pattern of the myogenic factors MyoD and myogenin was similar for both types of mice, while NCAM, which is associated with the initiation of fusion of muscle precursor cells, was more increased in the injured muscle of CCR2-/- mice. In conclusion, the study delineates that signaling through CCR2 is involved in muscle precursor cell activities necessary for complete and rapid regeneration of injured skeletal muscle.
Keywords
Skeletal-system; Muscles; Muscle-cells; Fibrosis; Laboratory-animals; Animals; Animal-studies
CODEN
FAJOEC
Publication Date
20050301
Document Type
Journal Article
Email Address
PSimeonova@cdc.gov
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0892-6638
NIOSH Division
HELD
Priority Area
Research Tools and Approaches: Exposure Assessment Methods
Source Name
The FASEB Journal
State
WV; GA; CA
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