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Preliminary findings that kerosene alters the distribution of topically applied benzo[a]pyrene in mice.

Authors
Schumann-BL; LaDow-K; Luse-N; Warshawsky-D; Pickens-W; Talaska-G; Pickens-B; Hoath-S
Source
Polycycl Aromat Compd 2004 Aug-Dec; 24(4/5):597-605
NIOSHTIC No.
20025877
Abstract
The dermal route is important in occupational exposure to polycyclic aromatic compounds (PACs), but other organs may be affected. We reported that kerosene-cleaning following treatment with used engine oil increased DNA adducts in the lungs of mice viz. animals treated with used oil alone. To determine the mechanism we topically applied 3H-BAP(100 nmol in 25 microL acetone) and washed half the mice with 25 microL kerosene 1 h after carcinogen application. Groups of four mice were sacrificed from 1 to 72 h after treatment. Lung, liver, and skin were harvested. The fraction of the radiolabel remaining in the skin of animals treated with benzo[a]pyrene (BAP) and washed with kerosene was significantly less than those not washed, beginning at 24 h (p < .05). Fractional distribution to the lungs and livers of these animals became significantly elevated. Kerosene increased transdermal water loss. Kerosene treatment compromises dermal barrier function, enhances carcinogen absorption, and alters organ distribution.
Keywords
Polycyclic-aromatic-hydrocarbons; Polycyclic-hydrocarbons; Skin-exposure; Petroleum-products; Animal-studies; Animals; Laboratory-animals; Metabolic-study
CODEN
PARCEO
Publication Date
20040801
Document Type
Journal Article
Funding Amount
690180
Funding Type
Grant
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-004124
Issue of Publication
4/5
ISSN
1040-6638
Priority Area
Research Tools and Approaches: Risk Assessment Methods
Source Name
Polycyclic Aromatic Compounds
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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