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Particulates and the airways: basic biological mechanisms of pulmonary pathogenicity.

Authors
Castranova-V
Source
Appl Occup Environ Hyg 1998 Aug; 13(8):613-616
NIOSHTIC No.
20025806
Abstract
With strong evidence that materials such as silica and asbestos are associated with irreversible lung disease, efforts have been made to identify abrasive substitute materials for silica and produce various synthetic vitreous fibers as substitutes for asbestos. With the introduction of new materials, questions concerning potential health effects are raised. A clear understanding of the mechanisms by witch certain inhaled particles induce lung damage and subsequent disease is vital to the ability to predict the relative safety of new materials, as well as, to provide appropriate measures for the safe use of old materials currently grouped together as particulates not otherwise classified/regulated. The following is a brief review of mechanisms currently thought to be important in the development and progression of particle-induced lung disease.
Keywords
Particulate-dust; Particulate-sampling-methods; Lung; Lung-disease; Lung-disorders; Lung-function; Lung-irritants; Cytotoxicity; Silica-dusts; Asbestos-dust; Asbestos-fibers; Pulmonary-function; Pulmonary-system-disorders
Contact
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
CODEN
AOEHE9
Publication Date
19980801
Document Type
Journal Article
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
8
ISSN
1047-322X
NIOSH Division
HELD
Source Name
Applied Occupational and Environmental Hygiene
State
WV
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