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Application of biological monitoring methods.

Teass-AW; Biagini-RE; DeBord-G; Hull-RD
NIOSH Manual of Analytical Methods, Fourth edition. Third supplement. Cincinnati, OH: National Institute for Occupational Safety and Health, 2003 Mar; :52-62
Biological monitoring is the assessment of worker exposure to a hazardous agent through the measurement of a biomarker which results from contact with the agent. The biomarker typically is the agent or its metabolite in a biological specimen derived from the worker; examples are styrene in expired air, styrene in blood, and mandelic and phenylglyoxylic acids (metabolites of styrene) in urine. The biomarker also can be an effect of the agent, such as elevated levels of zinc protoporphyrin in blood, caused by exposure to lead. Industrial hygiene professionals use biological monitoring to assess the risk to workers from exposure hazards and to demonstrate the adequacy of control technologies and intervention strategies. This chapter provides an overview of the effective and appropriate application of the biological monitoring analytical methods published herein. The analytical results should be interpreted in light of what is known about the uptake, metabolism, and excretion of the agent and the effect of the agent on the body. This chapter introduces these areas, provides other considerations, and gives references to sources of more comprehensive information on specific agents and situations. Additional resources on biological monitoring include reviews [1-10], books [11-17], and methods and quality assurance manuals [18-22].
Sampling-methods; Analytical-processes; Analytical-methods; Laboratory-equipment; Laboratory-techniques; Sample-preparation; Biomarkers
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NIOSH Manual of Analytical Methods, Fourth edition. Third supplement