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Differences in mortality by radiation monitoring status in an expanded cohort of Portsmouth Naval Shipyard workers.

Authors
Silver-SR; Daniels-RD; Taulbee-TD; Zaebst-DD; Kinnes-GM; Couch-JR; Kubale-TL; Yiin-JH; Schubauer Berigan-MK; Chen-PH
Source
J Occup Environ Med 2004 Jul; 46(7):677-690
NIOSHTIC No.
20025691
Abstract
Studies of leukemia and lung cancer mortality at the Portsmouth Naval Shipyard (PNS) have yielded conflicting results. In an expanded cohort of PNS workers employed between 1952 and 1992 and followed through 1996, the all-cause standardized mortality ratio (SMR) was 0.95 (95% confidence interval, 0.93-0.96). Employment duration SMRs were elevated with confidence intervals excluding 1.00 for lung cancer, esophageal cancer, and all cancers combined. Leukemia mortality was as expected overall, but standardized rate ratio analyses showed a significant positive linear trend with increasing external radiation dose. The role of solvent exposures could not be evaluated. Findings differed by radiation monitoring subcohort, with excess asbestosis deaths limited to radiation workers and several smoking-related causes of death higher among nonmonitored workers. At PNS, asbestos exposure and possibly smoking could be nonrandomly distributed with respect to radiation exposure, suggesting potential for confounding in internal analyses of an occupational cohort.
Keywords
Blood-disorders; Lung-cancer; Respiratory-system-disorders; Pulmonary-system-disorders; Pulmonary-cancer; Shipbuilding-industry; Shipyard-industry; Shipyard-workers; Shipyards; Mortality-data; Mortality-rates; Mortality-surveys; Statistical-analysis; Epidemiology; Solvents; Radiation-exposure; Radiation-hazards; Cigarette-smoking; Tobacco-smoke
Contact
Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226
CODEN
JOEMFM
CAS No.
1332-21-4
Publication Date
20040701
Document Type
Journal Article
Email Address
zre4@cdc.gov
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
7
ISSN
1076-2752
NIOSH Division
DSHEFS
Source Name
Journal of Occupational and Environmental Medicine
State
OH; ME
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