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Issues of design and analysis in studies of gene-environment interactions.

Authors
Vineis-P; Schulte-PA; Carreon-T; Bailer-AJ; Medvedovic-M
Source
Mechanisms of Carcinogenesis: Contributions of Molecular Epidemiology, IARC Publication No. 157. Lyon, France: International Agency for Research on Cancer, 2004 ; 157:417-435
Link
NIOSHTIC No.
20025620
Abstract
The nature-nurture debate has given way to the fundamental realization that both genes and environment play a role in disease, especially cancer. Interaction has been defined in several ways, for example as "the coparticipation of two or more agents in the same causal mechanism leading to disease development" (Yang and Khoury, 1997). According to a more generally accepted definition, interaction occurs when the effect of multiple factors differ from the effect predicted on the basis of the separate effects of each of the factors.
Keywords
Genes; Environmental-factors; Diseases; Cancer; Epidemiology; Carcinogens; Carcinogenesis; Carcinogenicity
Publication Date
20040101
Document Type
Book or book chapter
Email Address
paolo.vineis@unito.it
Editors
Buffler-P; Rice-J; Baan-R; Bird-M; Boffetta-P
Fiscal Year
2004
NTIS Accession No.
NTIS Price
ISBN No.
9283221575
Issue of Publication
157
NIOSH Division
EID
Source Name
Mechanisms of Carcinogenesis, Contributions of Molecular Epidemiology, IARC Publication No. 157.
State
OH
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