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Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters.

Authors
Burgess-JL; Fierro-MA; Lantz-RC; Hysong-TA; Fleming-JE; Gerkin-R; Hnizdo-E; Conley-SM; Klimecki-W
Source
J Occup Environ Med 2004 Oct; 46(10):1013-1022
NIOSHTIC No.
20025565
Abstract
During annual medical monitoring, some firefighters are found to have rates of decline in forced expiratory volume in one second (FEV1) far exceeding their peers. Interleukin-10 (IL-10) suppresses inflammation, and single nucleotide polymorphisms (SNPs) in the IL-10 gene may confer variable susceptibility to more rapid decline in lung function. In 1204 firefighters with at least six annual FEV1 measurements, increased age and greater initial FEV1 were associated with more rapid decline in lung function. DNA collected from 379 of these firefighters was screened for IL-10 SNPs at -1117, -854, 919, 1668, and 1812. A statistically significant difference in decline in lung function was found based on genotyping at the 1668 SNP. Evaluation of gene polymorphisms regulating lung inflammation may help to explain some of the variation in rate of decline in lung function in firefighters.
Keywords
Lung-function; Fire-fighters; Genes; Genetic-factors; Pulmonary-function-tests; Medical-monitoring; Nucleotides; Pulmonary-system-disorders; Lung-irritants; Toxic-gases; Smoking; Age-factors; Surveillance
Contact
Mel and Enid Zuckerman Arizona College of Purblic Health, Environmental and Occupational Health, 1435 N. Fremont, Tuscon, AZ 85719
CODEN
JOEMFM
Publication Date
20041001
Document Type
Journal Article
Email Address
jburgess@u.arizona.edu
Funding Amount
1174887
Funding Type
Grant
Fiscal Year
2005
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-CCT-918726
Issue of Publication
10
ISSN
1076-2752
NIOSH Division
DRDS
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease; Construction
Source Name
Journal of Occupational and Environmental Medicine
State
AZ; WV; CA
Performing Organization
University of California, School of Public Health, Los Angeles, California
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