Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Chronic neurological effects of organophosphate pesticides.

Authors
Steenland-K
Source
Br Med J 1996 May; 312(7042):1312-1313
NIOSHTIC No.
20025529
Abstract
Subclinical damage does occur, but longer follow up studies are needed Organophosphate pesticides have replaced organochlorines in the past 20 years and are widely used in both agricultural and structural applications. People working with these compounds receive the highest exposures, but the public can be exposed during structural applications or by drift from aerial spraying. The immediate toxic effects of organophosphates are well described; what remain controversial are the longer term effects. Organophosphates inhibit the neurotransmitter acetyl cholinesterase, leading to symptoms related to the autonomous nervous system (abdominal cramps, nausea, diarrhoea, salivation, miosis) and the central nervous system (dizziness, tremor, anxiety, confusion). Symptoms usually occur within hours of exposure and typically disappear within days or weeks as new cholinesterase is synthesised. The degree (or rate) of inhibition required to produce symptoms is controversial.
Keywords
Neurological-system; Neurological-diseases; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Pesticide-strips; Agricultural-industry; Agricultural-chemicals; Occupational-exposure; Exposure-levels; Toxic-effects; Central-nervous-system-disorders; Nervous-system-disorders
CODEN
BMJOAE
Publication Date
19960525
Document Type
Journal Article
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Issue of Publication
7042
ISSN
0959-8138
NIOSH Division
DSHEFS
Source Name
British Medical Journal
State
OH
TOP