Arsenic and atherosclerosis.
Toxicol Appl Pharmacol 2004 Aug; 198(3):444-449
Epidemiological studies have demonstrated a correlation between environmental or occupational arsenic exposure and a risk of vascular diseases related to atherosclerosis. Studies summarized in this review suggest that arsenic induces endothelial dysfunction, including inflammatory and coagulating activity as well as impairs nitric oxide (NO) balance. This may provide the pathophysiological basis for atherogenic potential of arsenic. Consistent with these data, arsenic accelerates atherosclerosis in apolipoprotein E (ApoE) deficient mice, a model of human atherosclerosis.
Arsenic-compounds; Epidemiology; Occupational-exposure; Environmental-exposure; Risk-factors; Risk-analysis; Laboratory-animals; Animals; Animal-studies; Cardiovascular-system-disease; Cardiovascular-system-disorders; Cardiovascular-system; Cardiovascular-disease; Veins
Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
Toxicology and Applied Pharmacology