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Arsenic and atherosclerosis.

Authors
Simeonova-PP; Luster-MI
Source
Toxicol Appl Pharmacol 2004 Aug; 198(3):444-449
NIOSHTIC No.
20025476
Abstract
Epidemiological studies have demonstrated a correlation between environmental or occupational arsenic exposure and a risk of vascular diseases related to atherosclerosis. Studies summarized in this review suggest that arsenic induces endothelial dysfunction, including inflammatory and coagulating activity as well as impairs nitric oxide (NO) balance. This may provide the pathophysiological basis for atherogenic potential of arsenic. Consistent with these data, arsenic accelerates atherosclerosis in apolipoprotein E (ApoE) deficient mice, a model of human atherosclerosis.
Keywords
Arsenic-compounds; Epidemiology; Occupational-exposure; Environmental-exposure; Risk-factors; Risk-analysis; Laboratory-animals; Animals; Animal-studies; Cardiovascular-system-disease; Cardiovascular-system-disorders; Cardiovascular-system; Cardiovascular-disease; Veins
Contact
Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
CODEN
TXAPA9
CAS No.
10102-43-9
Publication Date
20040801
Document Type
Journal Article
Email Address
psimeonova@cdc.gov
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0041-008X
NIOSH Division
HELD
Source Name
Toxicology and Applied Pharmacology
State
WV
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