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Pharmacological studies of the effect of wheat grain extract.

Authors
Schachter-EN; Zuskin-E; Rienzi-N; Goswami-S; Castranova-V; Siegel-P; Whitmer-M; Chung-E
Source
Respiration 2004 May-Jun; 71(3):276-283
NIOSHTIC No.
20025455
Abstract
Agricultural farm workers exposed to wheat grain dust are at risk of developing respiratory abnormalities. The pathogenesis of this injury is only partially understood. To determine the effect of wheat grain extract on isolated guinea pig tracheal smooth muscle. In the current study, pharmacologic properties of wheat grain extract (WGE) were tested using guinea pig tracheas studied in vitro. Dose-related contractions of nonsensitized guinea pig trachea were demonstrated using these extracts. Pharmacologic studies were performed by pretreating guinea pig tracheal tissue with drugs known to modulate smooth muscle contraction: atropine 10(-6)M, indomethacin 10(-6)M, pyrilamine 10(-6)M, acivicin 10(-5)M, nordihydroguaretic acid (NDGA) 10(-5)M, bromophenacyl bromide (BPB) 10(-5 )M, 3,4,5-trimethoxybenzoic acid-8-(diethylamino)-octyl ester TMB8 10(-5)M, captopril 10(-5)M and capsaicin 5 x 10(-6)M. WGE causes a dose-dependent constriction of guinea pig tracheal smooth muscle. Atropine, pyrilamine, TMB8 and acivicin significantly reduced the contractile effects of the WGE. Inhibition of contraction by blocking of other mediators was significant but less complete. We conclude that WGE causes a dose-related constriction of airway smooth muscle by nonimmunological mechanisms involving a variety of airway mediators and possibly cholinergic receptors.
Keywords
Pharmacology; Agricultural-workers; Agricultural-industry; Occupational-exposure; Dusts; Dust-particles; Dust-exposure; Risk-factors; Respiratory-system-disorders; Laboratory-animals; Animals; Animal-studies; In-vitro-studies
Contact
E. Neil Schachter, MD, The Mount Sinai School of Medicine, Box 1232, One Gustave L. Levy Place, New York, NY 10029-6574, USA
CODEN
RESPBD
Publication Date
20040501
Document Type
Journal Article
Email Address
neil.schachter@mssm.edu
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0025-7931
NIOSH Division
HELD
Source Name
Respiration
State
WV; NY
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