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Immunotoxicology: role of inflammation in chemical-induced hepatotoxicity.

Authors
Luster-MI; Simeonova-PP; Gallucci-RM; Matheson-JM; Yucesoy-B
Source
Int J Immunopharmacol 2000 Dec; 22(12):1143-1147
NIOSHTIC No.
20025427
Abstract
The liver, which is the major organ responsible for the metabolism of drugs and chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseases, such as autoimmunity, are responsible for producing mediators which can effect liver damage or repair. This review will summarize the authors' current understanding of how inflammatory processes influence hepatic pathology and repair following exposure to established hepatotoxic chemicals including carbon tetrachloride (CCl4), an industrial chemical, and acetaminophen (APAP), a widely used analgesic.
Keywords
Immunotoxins; Hepatotoxicity; Hepatocytes; Hepatotoxins; Liver-disorders; Liver-damage; Author Keywords: Immunotoxicology; Hepatotoxicity; Acetaminophen
Contact
Michael I. Luster, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA
CODEN
IJIMDS
CAS No.
56-23-5
Publication Date
20001201
Document Type
Journal Article
Email Address
mluster@cdc.gov
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Issue of Publication
12
ISSN
0192-0561
NIOSH Division
HELD
Source Name
International Journal of Immunopharmacology
State
WV
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