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The association of plasma IL-6 levels with functional disability in community-dwelling elderly.

Authors
Cohen-HJ; Pieper-CF; Harris-T; Rao-KMK; Currie-MS
Source
J Gerontology 1997 Jul; 52A(4):M201-M208
NIOSHTIC No.
20025391
Abstract
IL-6 is a multifunctional cytokine that has been shown to increase with age. Plasma IL-6 was measured by ELISA in 1,727 community-dwelling elderly subjects whose blood was drawn during the third in-person survey of the Duke Established Populations for Epidemiologic Studies of the Elderly (EPESE). Demographics, functional status (disability), and disease states were determined. Correlations of these factors with IL-6 were analyzed with Spearman's Rho while differences between groups were assessed by Wilcoxon test. IL-6 levels were higher with age (p = .0001) even in this older population (> 70 years). There was a positive correlation between IL-6 and functional disability for each of the functional status measures (p = .0001), as well as a correlation between self-rated health and IL-6. Significantly higher median levels of IL-6 were found in subjects reporting prevalent cancer, heart attack, and high blood pressure, but not diabetes or arthritis. The association between age and functional status with high IL-6 remained when all other variables were controlled, in multivariable analysis. This association between increased plasma IL-6 levels and functional status suggests that dysregulation of IL-6 may be related to the functional disability seen with aging, and that IL-6 may be useful as a component of an overall marker of health.
Keywords
Age-factors; Age-groups; Plasma-membrane; Humans; Surveillance-programs; Demographic-characteristics; Statistical-analysis
Contact
Dr. Harvey Jay Cohen, Box 3003, Duke University Medical Center, Durham, NC 27710
CODEN
JGASFW
Publication Date
19970701
Document Type
Journal Article
Fiscal Year
1997
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
1079-5006
NIOSH Division
HELD
Source Name
Journal of Gerontology
State
NC; MD; WV
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