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The potentiating action of tetrandrine in combination with chloroquine or qinghaosu against chloroquine-sensitive and resistant falciparum malaria.

Authors
Ye-Z; Dyke-KV; Castranova-V
Source
Biochem Biophys Res Comm 1989 Dec; 165(2):758-765
NIOSHTIC No.
20025323
Abstract
Using chloroquine-sensitive (CS) and chloroquine-resistant (CR) strains of Plasmodium falciparum in vitro, interactions between tetrandrine (TT) and either chloroquine (CQ) or qinghaosu (QHS, artemisinin) were assessed using isobolograms. Sums of the fractional inhibitory concentration for the combination of the two drugs are less than one and therefore, we can conclude that in vitro TT and CQ or QHS act synergistically against CS and CR falciparum malaria. Remarkably, using CR malaria, TT can lower the IC50 dose of CQ as much as 40 fold. These drug combinations may impair the advantage that the development of CQ resistance conveys on the parasite.
Keywords
In-vitro-study; Drugs; Drug-interaction; Drug-receptor; Diseases; Disease-control; Viral-diseases; Viral-infections; Microorganisms
CODEN
BBRCA9
Publication Date
19891215
Document Type
Journal Article
Fiscal Year
1990
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0006-291X
NIOSH Division
DRDS
Source Name
Biochemical Biophysical Research Communication
State
WV
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