Of mice men and models: future research for improving risk assessment methods, August 16-18, 2000, Aspen, Colorado.
NIOSH 2000 Aug; :1-10
Risk assessment has become an essential tool for developing occupational and environmental health and safety standards and other policies to protect workers and the public from hazardous exposures. Risk Assessment is a relatively new discipline and the currently available data and methods are often inadequate and/or controversial. The lack of consensus on what are appropriate methods for risk assessment has frequently led to acrimonious debates, which have been an impediment to the development of appropriate and expedient responses to environmental and occupational hazards. The source of the controversies are generally related to either the methods used for developing the toxicologic (e.g.. mice) or epidemiologic (e.g.. men) databases or to the methods used to develop mathematical predictions (e.g.. models) from these databases. Thus research is needed to develop methods that will enhance the relevance of toxicologic and epidemiologic data, and the credibility of models of the results from these studies for predicting the consequences from exposures to occupational and environmental hazards. The resulting improvements in the methodology used for risk assessments should lead to the greater acceptance of the results from risk assessments. and ultimately to improvements in the development of standards and policies designed to protect workers and the public from exposure to hazardous substances.
Risk-analysis; Risk-factors; Health-standards; Quantitative-analysis; Occupational-exposure; Occupational-health; Regulations; Toxic-dose; Toxicology; Employee-exposure; Epidemiology; Animal-studies; Exposure-limits; Dose-response; Mathematical-models
Risk Evaluation Branch, Education and Information Division, NIOSH C15, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA
EID; DART; DRDS; DSHEFS; DSR
National Institute for Occupational Safety and Health