Molecular mechanisms of antioxidant defense in the skin.
Toxicologist 2004 Mar; 78(S-1):251
Antioxidant deficiency is a component of nutrition shortage. A growing body of evidence suggests that exposure to a number of occupational and environmental toxicants caused oxidative stress leading to short or long-term antioxidant deficiency and cellular dysfunction. Antioxidants, including vitamin E, vitamin C, glutathione and beta-carotene are among the body's natural defense mechanisms against oxidative stress. The skin is recognized as a barrier to absorption, a primary target and route of entry to the systemic circulation. The skin cells may create an oxidative or reductive environment, depending on predominance of redox processes catalyzed by both enzymic and non-enzymic systems. The talk will focus on recent advances in genetic and molecular mechanisms of chemical induced oxidative skin injury, oxidation of skin cellular constituents by reactive oxygen species leading to necrotic/apoptotic death pathways, phospholipid oxidation and signaling, bio-markers of oxidative stress determined in human cells and skin tissues ob-tained from alimentary vitamin E deficient and knockout tocopherol (alpha) transporter protein Ttpa mice. Value of antioxidants in occupational exposures causing skin damage will be addressed.
Antioxidants; Occupational-exposure; Environmental-exposure; Toxic-effects; Toxins; Cellular-reactions; Skin-absorption; Skin-disorders; Skin-exposure; Biomarkers
Disease and Injury: Allergic and Irritant Dermatitis
The Toxicologist. Society of Toxicology 43nd Annual Meeting and ToxExpo, March 21-25, 2004, Baltimore, Maryland