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Ovulatory responses of adult mice treated neonatally with estradiol or methoxychlor (technical grade).

Authors
Eroschenko-VP; Swartz-WJ; Ford-LC
Source
FASEB J 1994 Apr; 8(5)(II):A959
NIOSHTIC No.
20025093
Abstract
Methoxychlor (MXC), a widely used organochlorine pesticide is estrogenic. To determine its effects on ovulation, one-day-old mice were exposed daily for 14 days to either sesame oil or 1.0 ug estradiol-17B (E), or 0.1 mg, 0.5 mg, or 1.0 mg MXC suspended in sesame oil. At two and four months of age, the animals were injected with a superovulatory regimen of 10 I.U. of pregnant mare's serum followed by 10 I.U. of human chorionic gonadotropin. The chemical treatments produced both a time- and dose- dependent changes. Ovulatory responses and ovarian weights were significantly reduced by two months of age in mice neonatally exposed to E, 0.5 mg, or 1.0 mg MXC. By four months of age, all treated animals exhibited a significant reduction in number of oocytes ovulated in response to exogenous gonadotropin. The ovaries in the treated mice also exhibited fewer fresh corpora lutea and an increase in the number of atretic follicles. It is concluded that neo natal methoxychlor exposures alter ovarian responses to exogenous gonadotropins, resulting in decreased ovulations.
Keywords
Reproductive-effects; Reproductive-hazards; Reproductive-system-disorders; Laboratory-animals; Insecticides; Toxic-effects; Pesticides; Pregnancy; Prenatal-exposure; Risk-factors; Exposure-levels; Dose-response
CODEN
FAJOEC
CAS No.
72-43-5; 72-43-5
Publication Date
19940424
Document Type
Abstract; Conference/Symposia Proceedings
Funding Amount
1256842
Funding Type
Grant
Fiscal Year
1994
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00835
Issue of Publication
5
ISSN
0892-6638
NIOSH Division
OEP
Source Name
The FASEB Journal. Experimental Biology '94, Anaheim, California, April 24-28, 1994
State
LA
Performing Organization
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana
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