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Persistent specific airway responsiveness in rats sensitized to and challenged with trimellitic anhyrdride (TMA).

Authors
Siegel-PD; Zhang-X; Lewis-DM
Source
Toxicologist 2004 Mar; 78(S-1):48
NIOSHTIC No.
20025045
Abstract
TMA is an organic acid anhydride that is widely used in industry. It can induce specific IgE and cause occupational asthma in sensitized individuals. Persistent occupational asthma, even with antigen/hapten avoidance can be seen is approximately 20% of the cases. Duration of both circulating TMA-specific IgE and specific airway responsiveness was studied in a TMA sensitized Brown Norway rat asthma model as possible contributory factors to persistent asthma. TMA powder (4 mg) was applied to 4 anesthetized rats' backs (clipped with scissors) on days 0, 7, 14 and 21 and washed off after 4 hrs. Specific IgE analyses and airway challenge with TMA (40 mg/m 3 for 10 min) were performed on day 35 and day 386. The ELISA OD values for TMA-specific IgE were 0.46 +/- 0.07 and 0.12 +/- 0.02 on day 35 and day 386, respectively (non-specific binding from control sera OD=0.08 +/- 0.002). Dual, early- (EAR) and late-phase (LAR) airway responses (indicated by enhanced pause, an index of airway resistance) were observed on day 35. A dual response was noted upon rechallenge on day 386 in 3 rats and LAR-only in the 4th rat. These results demonstrate the persistence of specific airway responsive-ness to TMA, even though circulating specific-IgE had drastically declined.
Keywords
Airway-obstruction; Airway-resistance; Laboratory-animals; Animals; Animal-studies; Organic-acids; Bronchial-asthma; Models; Pulmonary-system-disorders; Respiratory-system-disorders
CAS No.
552-30-7
Publication Date
20040301
Document Type
Abstract
Fiscal Year
2004
NTIS Accession No.
NTIS Price
ISSN
1096-6080
NIOSH Division
HELD
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
The Toxicologist. Society of Toxicology 43nd Annual Meeting and ToxExpo, March 21-25, 2004, Baltimore, Maryland
State
MD; WV
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