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Roles of epidemiology, pathology, molecular biology, and biomarkers in the investigation of occupational lung cancer.

Authors
Vallyathan-V; Green-F; Ducatman-B; Schulte-P
Source
J Toxicol Environ Health, B 1998 Apr-Jun; 1(2):91-116
NIOSHTIC No.
20025041
Abstract
The pathology and molecular biology of lung cancer demonstrate that these tumors evolve through a series of mutations, molecular changes, and corresponding morphologic changes. To elucidate how occupational and environmental factors influence lung cancer histogenesis it is important not only to understand epidemiology and the interactions between etiologic agents but also to integrate information from pathology, biochemistry and molecular biology. This review focuses on the range of techniques currently available for characterizing lung cancer and how their prudent use can be beneficial in the identification of occupational carcinogens. Because many occupational and environmental lung cancers are caused by multiple etiologic agents, the integration of histology with cellular, biochemical and molecular biomarker techniques may provide new approaches for understanding the disease process.
Keywords
Pathology; Molecular-biology; Molecular-structure; Lung; Lung-disorders; Lung-disease; Lung-cancer; Tumors; Morphology; Histomorphology; Pulmonary-system-disorders; Respiratory-system-disorders
Contact
Dr. Val Vallyathan, Pathology and Physiology Research Branch, HELD, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
CODEN
JTECFR
Publication Date
19980401
Document Type
Journal Article
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1093-7404
NIOSH Division
HELD; EID
Source Name
Journal of Toxicology and Environmental Health, Part B: Critical Reviews
State
WV; OH
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