Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Thermoregulation in rats exposed perinatally to dioxin: core temperature stability to altered ambient temperature, behavioral thermoregulation, and febrile response to lipopolysaccharide.

Authors
Gordon-CJ; Miller-DB
Source
J Toxicol Environ Health, A 1998 Aug; 54(8):647-662
NIOSHTIC No.
20025000
Abstract
Recent studies have shown that perinatal exposure to 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD, dioxin) alters thermoregulatory function in adult rats and hamsters, indicated by a reduced body temperature during the animal's nocturnal phase. The present study was designed to assess the behavioral thermoregulation, ability to develop a fever, and thermoregulatory stability as a function of ambient temperature (Ta) in rats exposed perinatally to TCDD. Pregnant Long-Evans rats were exposed on gestational day (GD) 15 to 1 mug TCDD/kg (po). The male offspring were implanted with transmitters to monitor core temperature (Tc) and motor activity (MA). The 24-h pattern of core temperature was affected by TCDD exposure, characterized by a reduced nocturnal Tc. At some ages, the diurnal Tc of the TCDD group was elevated. This dysfunction in temperature regulation was most apparent at 7 and 11 mo of age. The 24-h pattern of MA was also altered by TCDD. The hypothermic effects of TCDD were most pronounced at cooler T values a of 10 to 22 C. In contrast, behavioral thermoregulation, assessed by measuring the selected Ta and Tc of rats in a temperature gradient, was unaffected by TCDD. The ability to develop a fever following administration of lipopolysaccharide (LPS) endotoxin (Escherichia coli; 50 mug/ kg) was accentuated in the TCDD-treated animals. The data confirm a nocturnal hypothermia in rats prenatally exposed to TCDD. However, the normal behavioral regulation of Tc suggests that hypothalamic thermoregulatory centers are not permanently altered. The accentuated fever in TCDD animals shows possible functional alterations in the neuroimmune and/or thermoregulatory axes involved in fever.
Keywords
Animal-studies; Animals; Laboratory-animals; Dioxins; Thermoregulation; Temperature-measurement; Temperature-effects; Temperature-control
Contact
Dr. C. J. Gordon, MD-74B, U.S. EPA, Research Triangle Park, NC 27711, USA
CODEN
JTEHD6
CAS No.
1746-01-6
Publication Date
19980815
Document Type
Journal Article
Email Address
gordon@herl45.herl.epa.gov
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
8
ISSN
0098-4108
NIOSH Division
HELD
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV
TOP