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Effects of microgravity and bone morphogenetic protein II on GFAP in rat brain.

Authors
Day-JR; Frank-AT; O'Callaghan-JP; DeHart-BW
Source
J Appl Physiol 1998 Aug; 85(2):716-722
NIOSHTIC No.
20024964
Abstract
This study evaluated effects of bone morphogenetic protein II (BMP) on glial fibrillary acidic protein (GFAP) in the brain of female Fischer 344 rats during 14 days of spaceflight. GFAP mRNA decreased in vehicle-implanted rats flown on the space shuttle by 53 and 48% in the stratum moleculare and stratum lacunosum moleculare hippocampal subregions, respectively. GFAP mRNA was not significantly affected by BMP implantation during spaceflight. Rats returning from space exhibited a 56% increase in serum corticosterone. BMP treatment did not additively increase corticosterone elevations in microgravity but appeared to increase serum corticosterone and reduce GFAP mRNA in the stratum moleculare in control rats. These data suggest that exposure to microgravity reduces GFAP expression in hippocampal astrocytes.
Keywords
Brain-function; Animals; Animal-studies; Space-physiology; Brain-matter; Laboratory-animals; Central-nervous-system
CODEN
JAPHEV
Publication Date
19980801
Document Type
Journal Article
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
8750-7587
NIOSH Division
HELD
Source Name
Journal of Applied Physiology
State
WV
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