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Vanadium- and chromium-induced cell signal transduction.

Authors
Qian-Y; Shi-X
Source
Oxygen/Nitrogen Radicals: Lung Injury and Disease (Lung Biology in Health and Disease). Vol. 187. New York: Marcel Dekker, 2004 Apr; 187:475-492
Link
NIOSHTIC No.
20024916
Abstract
Both vanadium and chromium are two common toxic metals. Accumulating evidence indicates that exposure of humans to either metal induces a wide spectrum of adverse effects, including carcinogencity. neurotoxicity. and immunotoxicity. Among these adverse effects, carcinogencity is the major geological consequence. The underlying molecular mechanisms have not been fully identified yet. For the past several years, much attention has been focused on how these two metals alter cellular signal transduction to lead to carcinogenesis. This chapter will serve as a summary of recent advances in the knowledge base for cellular signal transduction, including induction of tyrosine phosphorylation. phosphatidylinositol 3-kinase (PI3 kinase) signaling, nuclear factor-kB (NF-kB) activation, cell cycle arrest, and apoptosis,in response to vanadium or chrominum.
Keywords
Vanadium-compounds; Chromium-compounds; Metals; Toxins; Toxic-effects; Toxic-materials; Carcinogenicity; Carcinogenesis; Cell-function; Cellular-reactions; Neurotoxic-effects; Neurotoxins; Immunotoxins
CAS No.
7440-62-2; 7440-47-3
Publication Date
20040501
Document Type
Book or book chapter
Editors
Vallyathan-V; Castranova-V; Shi-X
Fiscal Year
2004
NTIS Accession No.
NTIS Price
ISBN No.
0824748743
NIOSH Division
HELD
Source Name
Oxygen/Nitrogen Radicals: Lung Injury and Disease (Lung Biology in Health and Disease)
State
WV
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