Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

CYP17 genotype and breast cancer risk.

Authors
Weston-A; Pan-C-F; Bleiweiss-IJ; Ksieski-HB; Roy-N; Maloney-N; Wolff-MS
Source
Cancer Epidemiol Biomark Prev 1998 Oct; 7(10):941-944
NIOSHTIC No.
20024904
Abstract
The MspAI polymorphism in the 5' untranslated region of CYP17 has been evaluated as a breast cancer risk factor in a hospital-based case-control study in New York City. The study population consisted of 363 women [123 breast cancer patients and 240 patient controls (123 benign breast disease without atypical hyperplasia, 117 women without breast disease)]. There were 224 Caucasians (76 cases, 148 controls), 55 African-Americans (20 cases, 35 controls) and 84 Hispanics (27 cases, 57 controls); 142 premenopausal women and 221 postmenopausal women. Consistent with a previous report (Feigelson et al., Cancer Res., 57: 1063-1065, 1997) we found no evidence to implicate the minor variant (restriction site present allele, designated A2) as a breast cancer risk factor. Furthermore, we sought evidence to implicate the minor variant of CYP17 in the development of more aggressive breast cancers (n = 38/121) as had been reported previously. Although confidence intervals (CI) overlap, the data presented here do not provide support for previously reported findings (odds ratio, 0.9; 95% CI, 0.4-2.0; n = 38 versus odds ratio, 2.5; 95% CI, 1.1-5.2; n = 40). Clearly this question needs to be resolved in a larger study. No evidence was found to support the contention that inheritance of the minor variant is a predictor of early age at menarche. Allelic frequencies between different ethnic groups were not found to be different with the exception of Hispanic controls, in which the genotypic distribution was not consistent with the Hardy-Weinberg equilibrium.
Keywords
Cancer; Cancer-rates; Breast-cancer; Women; Statistical-analysis; Gene-mutation; Mutagenicity; Racial-factors; Demographic-characteristics; Statistical-analysis
Contact
NIOSH-CDC, MS 3014, HELD-TMBB, 1095 Willowdale Road, Morgantown WV 26505-2888
CODEN
CEBPE4
Publication Date
19981001
Document Type
Journal Article
Email Address
agw8@cdc.gov
Fiscal Year
1999
NTIS Accession No.
NTIS Price
Issue of Publication
10
ISSN
1055-9965
NIOSH Division
HELD
Source Name
Cancer Epidemiology, Biomarkers & Prevention
State
WV
TOP