A chemical exposure assessment strategy developed to analyze solvent exposures at the Department of Energy Hanford Site.
American Industrial Hygiene Conference and Exposition, May 8-13, 2004, Atlanta, Georgia. Fairfax, VA: American Industrial Hygiene Association, 2004 May; :87
Retrospective chemical exposure assessment for carbon tetrachloride and benzene at the DOE Hanford site has been developed as part of a multisite case-control study of leukemia among radiation exposed workers. The overall study purpose is to explore the relationship between low-level radiation exposure and death from leukemia, while accounting for potential confounding by internal radiation and chemical exposures. A job exposure matrix was created from work histories, process descriptions, chemical inventories, and monitoring records. Less than a dozen air samples for these agents were identified. Examination of the process documents at Hanford from 1944 to 1996 identified uses of benzene and carbon tetrachloride. Potential benzene exposure was limited to 8 activities. The potential for carbon tetrachloride exposure was identified in 13 activities. Of 908 chemical inventory records for Hanford, 2 reported benzene, and 8 reported the presence of carbon tetrachloride. Work histories for the 495 Hanford workers were extracted from available data at NIOSH which was supplemented from information from other employment and medical records from Hanford. Job titles, organization codes, and buildings were identified for the time periods worked. The three most frequent job titles were: power operator, clerk, and engineer. The percentage of person-years with an identified job title is 95.6%, with an organization code is 81.7%, and with an identified building is 62.8%. Comparison of these three factors allowed imputation of the missing values. Categories of exposure opportunities to these two chemicals were derived for the epidemiologic analysis.
Solvents; Occupational-exposure; Workers; Work-environment; Benzenes; Radiation; Radiation-exposure; Air-samples; Epidemiology; Blood-disorders; Nuclear-hazards; Cancer; Cancer-rates
American Industrial Hygiene Conference and Exposition, May 8-13, 2004, Atlanta, Georgia