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Role of nitric oxide in pathological responses of the lung to exposure to environmental/occupational agents.

Authors
Zeidler-PC; Castranova-V
Source
Redox Rep 2004 Jan; 9(1):7-18
NIOSHTIC No.
20024700
Abstract
Conflicting evidence exists as to whether nitric oxide expresses damaging/inflammatory or antioxidant/anti-inflammatory properties. Data presented in this review indicate that in vitro or in vivo exposure to selected environmental or occupational agents, such as asbestos, silica, ozone or lipopolysaccharide, can result in up-regulation of inducible nitric oxide synthase by alveolar macrophages and pulmonary epithelial cells. In the case of silica exposure, evidence consistently supports a damaging/inflammatory role of nitric oxide and/or peroxynitrite in the pathogenesis of lung disease. Although conflicting data have been reported, the majority of published studies suggest that nitric oxide plays a damaging role in pulmonary injury resulting from exposure to ozone or asbestos. In contrast, most information supports an anti-inflammatory role of nitric oxide following exposure to lipopolysaccharide. Further investigation is required to elucidate fully the mechanisms involved in determining the role of nitric oxide in the initiation and progression of various pulmonary diseases.
Keywords
Oxides; Nitrates; Pathology; Occupational-exposure; Environmental-exposure; Lung-disorders; Pulmonary-system-disorders; Respiratory-system-disorders; Antioxidants; Silica-dusts; Silicates; Lung-disease
Contact
Vincent Castranova PhD, Chief, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, M/S L-2015, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
CODEN
RDRPE4
CAS No.
10102-43-9; 7631-86-9
Publication Date
20040101
Document Type
Journal Article
Email Address
vic1@cdc.gov
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1351-0002
NIOSH Division
HELD
Source Name
Redox Report
State
WV
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