Role of nitric oxide in pathological responses of the lung to exposure to environmental/occupational agents.
Redox Rep 2004 Jan; 9(1):7-18
Conflicting evidence exists as to whether nitric oxide expresses damaging/inflammatory or antioxidant/anti-inflammatory properties. Data presented in this review indicate that in vitro or in vivo exposure to selected environmental or occupational agents, such as asbestos, silica, ozone or lipopolysaccharide, can result in up-regulation of inducible nitric oxide synthase by alveolar macrophages and pulmonary epithelial cells. In the case of silica exposure, evidence consistently supports a damaging/inflammatory role of nitric oxide and/or peroxynitrite in the pathogenesis of lung disease. Although conflicting data have been reported, the majority of published studies suggest that nitric oxide plays a damaging role in pulmonary injury resulting from exposure to ozone or asbestos. In contrast, most information supports an anti-inflammatory role of nitric oxide following exposure to lipopolysaccharide. Further investigation is required to elucidate fully the mechanisms involved in determining the role of nitric oxide in the initiation and progression of various pulmonary diseases.
Oxides; Nitrates; Pathology; Occupational-exposure; Environmental-exposure; Lung-disorders; Pulmonary-system-disorders; Respiratory-system-disorders; Antioxidants; Silica-dusts; Silicates; Lung-disease
Vincent Castranova PhD, Chief, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, M/S L-2015, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA