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Some implications of genetic biomarkers in occupational epidemiology and practice.

Authors
Schulte-PA
Source
Scand J Work, Environ & Health 2004 Feb; 30(1):71-79
NIOSHTIC No.
20024575
Abstract
This paper addresses the use of genetic biomarkers in occupational epidemiology and some of the scientific, ethical, and social implications for epidemiologists and practitioners to consider, including issues involving individual risk estimation, the communication of epidemiologic results, and the translation of epidemiologic data into clinical or occupational health practice. Three scenarios from the occupational setting illustrate some of these issues and implications. The scenarios involve glutathione-S-transferase theta 1 (GSTT1) and hematopoietic cancer in hospital workers, human leukocyte antigen coding for glutamic acid in the 69th position (HLA DPB1(E69)) and chronic beryllium disease in beryllium workers, and peripheral myelin protein 22 (PMP22) deletion and carpal tunnel syndrome in railroad track workers. Epidemiologic research involving genetic biomarkers requires the application of genetic tests and can be considered on a continuum between basic sciences and clinical and occupational and public health practice for which questions of test relevance, validity, and utility become important.
Keywords
Genetics; Biomarkers; Epidemiology; Risk-analysis; Risk-factors; Occupational-health; Health-care-personnel; Cancer; Beryllium-compounds; Beryllium-disease; Carpal-tunnel-syndrome
Contact
Dr. PA Schulte, NIOSH, MS-C14, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
CODEN
SWEHDO
CAS No.
7440-41-7
Publication Date
20040201
Document Type
Journal Article
Email Address
pas4@cdc.gov
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0355-3140
NIOSH Division
EID
Source Name
Scandinavian Journal of Work, Environment and Health
State
OH
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