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Is silicosis required for silica-associated lung cancer?

Authors
Checkoway-H; Franzblau-A
Source
Am J Ind Med 2000 Mar; 37(3):252-259
NIOSHTIC No.
20024512
Abstract
Abundant epidemiologic and experimental evidence supports the 1997 International Agency for Research on Cancer classification of crystalline silica as a human lung carcinogen. Nonetheless, there remains uncertainty about whether excessive lung cancer occurs exclusively among workers with silicosis. A review was performed of published occupational epidemiologic literature directly pertinent to the interrelations among silica exposure, silicosis, and lung cancer. The association between silica and lung cancer is generally, but not uniformly, stronger among silicotics than nonsilicotics. However, the existing literature is ambiguous due to incomplete or biased ascertainment of silicosis, inadequate exposure assessment, and the inherently strong correlation between silica exposure and silicosis which hinders efforts to disentangle unique contributions to lung cancer risk. Until more conclusive epidemiologic findings become available, population-based or individually-based risk assessments should treat silicosis and lung cancer as distinct entities whose cause/effect relations are not necessarily linked.
Keywords
Occupational-exposure; Exposure-levels; Workers; Work-environment; Epidemiology; Biomarkers; Silicosis; Risk-factors; Silicates; Silica-dusts; Lung-cancer; Pulmonary-system-disorders; Respiratory-system-disorders; Pneumoconiosis; Occupational-health; Author Keywords: silica; silicosis; lung cancer; pneumoconiosis; occupational health
Contact
Harvey Checkoway, University of Washington, Department of Environmental Health, Box 357234 Seattle, WA 98195-7234
CODEN
AJIMD8
CAS No.
14808-60-7
Publication Date
20000301
Document Type
Journal Article
Email Address
checko@u.washington.edu
Funding Amount
381670
Funding Type
Grant
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003126
Issue of Publication
3
ISSN
0271-3586
Source Name
American Journal of Industrial Medicine
State
WA
Performing Organization
University of Washington, Seattle, Washington
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