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Radiographic evidence of silicosis risk in the diatomaceous earth industry.

Authors
Hughes-JM; Weill-H; Checkoway-H; Jones-RN; Henry-MM; Heyer-NJ; Seixas-NS; Demers-PA
Source
Am J Respir Crit Care Med 1998 Sep; 158(3):807-814
NIOSHTIC No.
20024507
Abstract
There is limited and conflicting evidence regarding the exposure-response relationship between exposure to crystalline silica and silicosis; the level of risk to current workers remains uncertain. We conducted an epidemiologic investigation of 1,809 workers in the diatomaceous earth industry, where exposures to crystalline silica are primarily to the cristobalite form. On the basis of the median of three independent readings, 81 (4.5%) workers were judged to have opacities on chest radiographs (small opacities, profusion 1/0, and/or large opacities). Age-adjusted relative risk of opacities increased significantly with cumulative exposure to crystalline silica. The concentration of respirable crystalline silica to which workers were exposed (highly correlated with period of hire) was an important determinant of risk after accounting for cumulative exposure. For workers with an average exposure to crystalline silica of 0.50 mg/m3 (or hired 1950), the cumulative risk of opacities for a cumulative exposure to crystalline silica of 2.0 mg/m3-yr was approximately 1.1%; for an average exposure > 0.50 mg/m3 (or hired < 1950), the corresponding cumulative risk was 3.7%. These findings indicate an exposure-response relationship between cumulative exposure to crystalline silica and radiographic opacities; moreover, the relationship was substantially steeper among workers exposed at the highest average concentrations of crystalline silica.
Keywords
Occupational-exposure; Exposure-levels; Workers; Work-environment; Epidemiology; Biomarkers; Silicosis; Risk-factors; Silicates; Silica-dusts
Contact
Dr. Janet M. Hughes, Department of Biostatistics and Epidemiology, SL18, Tulane University Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112
CODEN
AJCMED
CAS No.
14808-60-7; 7631-86-9
Publication Date
19980901
Document Type
Journal Article
Email Address
hughes@mailhost.tcs.tulane.edu
Funding Amount
381670
Funding Type
Grant
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003126
Issue of Publication
3
ISSN
1073-449X
Source Name
American Journal of Respiratory and Critical Care Medicine
State
WA
Performing Organization
University of Washington, Seattle, Washington
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