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Fibrosis and intercellular collagen connections from four weeks of muscle strains.

Authors
Stauber-WT; Knack-KK; Miller-GR; Grimmett-JG
Source
Muscle Nerve 1996 Apr; 19(4):423-430
NIOSHTIC No.
20024459
Abstract
The effect of repeated cycles of muscle strain was studied in the soleus muscle of female rats. Muscle strains were repeated 3X/week for 1 month using two different strain protocols. Striking changes, including marked variability in fiber size, evidence of degradation and regeneration, and an expanded extracellular matrix were pronounced in the fast-stretched muscles but not in the slow-stretched muscles. However, the slow-stretched muscles did contain struts of connective tissue joining adjacent myofibers. Therefore, repeated muscle strains at high strain rates produced morphological changes similar to many myopathies, including fibrosis, whereas adaptation occurred in response to the same number of strains at slow strain rates. Such diverse tissue responses have relevance to the understanding of the mechanisms of skeletal muscle dysfunction in cumulative trauma disorders and in the design of preventive actions and treatments.
Keywords
Fibrosis; Collagen-fibrils; Muscle-stress; Laboratory-animals; Animals; Animal-studies; Morphology; Cumulative-trauma; Cumulative-trauma-disorders; Musculoskeletal-system-disorders; Muscle-tissue; Injury-prevention
Contact
William T. Stauber, PhD, Department of Physiology, West Virginia University, PO Box 9229, Morgantown, WV 26506-9229
CODEN
MUNEDE
Publication Date
19960401
Document Type
Journal Article
Funding Amount
868663
Funding Type
Grant
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002918
Issue of Publication
4
ISSN
0148-639X
Source Name
Muscle and Nerve
State
WV
Performing Organization
West Virginia University, Morgantown, West Virginia
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