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Exercise alters serum pneumoprotein concentrations.

Authors
Nanson-CJ; Burgess-JL; Robin-M; Bernard-AM
Source
Respir Physiol 2001 Sep; 127(2-3):259-265
NIOSHTIC No.
20024418
Abstract
To determine the effect of exercise on serum levels of Clara cell protein (CC16) and surfactant-associated protein A (SP-A), serum was collected from 14 healthy subjects 1 h after maximal and sub-maximal exercise. Healthy volunteers participated on separate occasions in a control (no exercise) session, simulated firefighting tasks for 30 min (n=14), and intermittent treadmill exercise at near maximal heart rates for 60 min (n=10). Serum samples and induced sputum samples were collected 1 h post exercise. Induced sputum fluid was analyzed for tumor necrosis factor alpha (TNF-alpha), an inflammatory mediator produced by pulmonary macrophages. Serum CC16 levels increased significantly with both firefighting tasks (15+/-13 microg/L vs. 9+/-4 microg/L, P=0.047) and treadmill exercise (15+/-8 microg/L vs. 9+/-4 microg/L, P<0.01). Serum SP-A concentrations did not change compared to control with either firefighting tasks (247+/-106 microg/L vs. 247+/-96 microg/L, P=0.84) or treadmill exercise (251+/-89 microg/L vs. 285+/-87 microg/L, P=0.44). TNF-alpha concentrations in sputum supernatant showed no significant difference from controls. These results show an increase in serum CC16 after exercise. This must be considered when utilizing serum CC16 to determine the presence of lung injury in settings that combine exercise and toxic exposures.
Keywords
Fire-fighting; Fire-fighters; Fire-protection-equipment; Pulmonary-system-disorders; Personal-protective-equipment; Respiratory-protective-equipment; Respiratory-system-disorders; Toxic-effects; Toxins; Author Keywords: Airways, sputum; Exercise; serum proteins; Mammals; humans; Mediators; TNF-a; Protein; Clara cell; surfactant-associated protein A
Contact
Division of Community and Environmental Health Practice and Policy, The Arizona College of Public Health, 1435 N. Fremont, Tucson, AZ 85719, USA
CODEN
RSPYAK
Publication Date
20010901
Document Type
Journal Article
Email Address
jburgess@u.arizona.edu
Funding Amount
162000
Funding Type
Grant
Fiscal Year
2001
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000172
Issue of Publication
2-3
ISSN
0034-5687
Source Name
Respiration Physiology
State
AZ
Performing Organization
University of Arizona, Tucson, Arizona
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