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Variability in airborne and biological measures of exposure to mercury in the chloralkali industry: implications for epidemiologic studies.

Authors
Symanski-E; Sallsten-G; Barregard-L
Source
Environ Health Perspect 2000 Jun; 108(6):569-573
NIOSHTIC No.
20024411
Abstract
Exposure assessment is a critical component of epidemiologic studies, and more sophisticated approaches require that variation in exposure be considered. We examined the intra- and interindividual sources of variation in exposure to mercury vapor as measured in air, blood, and urine among four groups of workers during 1990-1997 at a Swedish chloralkali plant. Consistent with the underlying kinetics of mercury in the body, the variability of biological measures was dampened considerably relative to the variation in airborne levels. Owing to the effects of intraindividual variation, estimating workers' exposures from a few measurements can attenuate measures of effect. To examine such effects on studies relating long-term exposure to a continuous health outcome, we evaluated the utility of each exposure measure by comparing the necessary sample sizes required for accurate estimation of a slope coefficient obtained from a regression analysis. No single measure outperformed the others for all groups of workers. However, when workers were evaluated together, creatinine-corrected urinary mercury better discriminated workers' exposures than airborne or blood mercury levels. Thus, pilot studies should be conducted to examine variability in both air and biomonitoring data because quantitative information about the relative magnitude of the intra- and interindividual sources of variation feeds directly into our efforts to design an optimal sampling strategy when evaluating health risks associated with occupational or environmental contaminants.
Keywords
Biological-monitoring; Occupational-exposure; Epidemiology; Exposure-methods; Styrenes; Air-contamination; Exposure-levels; Worker-health; Work-environment; Mercury-compounds; Airborne-particles; Occupational-health; Environmental-contamination; Heavy-metals
Contact
E. Symanski, 1200 Herman Pressler Drive, RAS Suite W-642, Houston, TX 77030 USA
CODEN
EVHPAZ
CAS No.
7439-97-6
Publication Date
20000601
Document Type
Journal Article
Email Address
esymanski@sph.uth.tmc.edu
Funding Amount
161676
Funding Type
Grant
Fiscal Year
2000
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000166
Issue of Publication
6
ISSN
0091-6765
Source Name
Environmental Health Perspectives
State
TX
Performing Organization
University of Texas School of Public Health, Houston, Texas
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