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Asthmalike biphasic airway responses in Brown Norway rats sensitized by dermal exposure to dry trimellitic anhydride powder.

Authors
Zhang-XD; Fedan-JS; Lewis-DM; Siegel-PD
Source
J Allergy Clin Immunol 2004 Feb; 113(2):320-326
NIOSHTIC No.
20024355
Abstract
Trimellitic anhydride (TMA) can induce specific IgE and occupational asthma. The significance of dermal exposure to TMA in immunologic sensitization and on subsequent airway responses is not clearly known. An animal model displaying both an early-phase airway response (EAR) and a late-phase airway response (LAR) after sensitization and subsequent inhalation challenge to a low-molecular-weight chemical has not been previously reported. The present study investigated EAR and LAR after TMA inhalation challenge in Brown Norway rats sensitized by skin exposure to TMA dry powder. Twenty milligrams of dry TMA powder was applied to the skin of each clipped rat's dorsum on days 0, 7, 14, and 21 and occluded overnight with surgical tape. Rats were challenged for 10 minutes with 0.2 to 40 mg/m(3) of TMA aerosol after day 35. Enhanced pause (an index of airway resistance) was recorded overnight in a whole-body plethysmography system. Specific IgE and pulmonary eosinophilia were also measured. Concentration-dependent responses to TMA were observed: provocation with 0.2 mg/m(3) produced no response; 1 mg/m(3) induced only EAR; and 5 mg/m(3) and 40 mg/m(3) induced both EAR and LAR. Specific IgE was positive; airway eosinophilic inflammation was observed. TMA powder applied to the skin can lead to both immunologic sensitization and subsequent dose-dependent biphasic airway responses after TMA aerosol challenge.
Keywords
Chemical-properties; Resins; Dyes; Dye-industry; Adhesives; Polymers; Printing-inks; Pharmaceuticals; Plasticizers; Agricultural-chemicals; Allergic-reactions; Allergic-dermatitis; Mucous-membranes; Immune-reaction; Laboratory-animals; Animals; Animal-studies
Contact
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. Morgantown, WV, USA
CODEN
JACIBY
CAS No.
552-30-7
Publication Date
20040201
Document Type
Journal Article
Email Address
xzhang@cdc.gov
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0091-6749
NIOSH Division
HELD
Priority Area
Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
Source Name
Journal of Allergy and Clinical Immunology
State
WV
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