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NF-kappaB prevents cells from undergoing Cr(VI)-induced apoptosis.

Authors
Wang-S; Chen-F; Zhang-Z; Jiang-B; Jia-L; Shi-X
Source
Mol Cell Biochem 2004 Jan; 255(1-2):129-137
NIOSHTIC No.
20024346
Abstract
The transcription factor NF-kappaB has been reported to prevent cells from undergoing apoptosis as well as promote cell apoptosis. To investigate the role of NF-kappaB in Cr(VI)-induced apoptosis, two cell lines were developed from human bronchial epithelial BEAS-2B cells: IKK cells, which were stably transfected with Ikappa-Ba expression vector, that have normal NF-kappaB activity, and KM cells, which were stably transfected with mutated Ikappa-Ba kinase expression vector, that exhibit very little NF-kappaB activity. With Cr(VI) stimulation, KM cells, but not IKK cells, exhibited substantial cell death. Cell morphological and TUNEL analyses indicated that the KM cells showed apoptotic features. These results suggest that NF-kappaB activation is required to prevent the cells from undergoing Cr(VI)-induced apoptosis.
Keywords
Cell-alteration; Cell-function; Humans; Mutation; Cell-biology; Cell-morphology
Contact
College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA.
CODEN
MCBIB8
Publication Date
20040101
Document Type
Journal Article
Email Address
jliu@unm.edu
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0300-8177
NIOSH Division
HELD
Source Name
Molecular and Cellular Biochemistry
State
NM; WV
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