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Oxidative mechanism of arsenic toxicity and carcinogenesis.

Authors
Shi-H; Shi-X; Liu-KJ
Source
Mol Cell Biochem 2004 Jan; 255(1-2):67-78
NIOSHTIC No.
20024345
Abstract
Arsenic is a known toxin and carcinogen that is present in industrial settings and in the environment. The mechanisms of disease initiation and progression are not fully understood. In the last a few years, there has been increasing evidence of the correlation between the generation of reactive oxygen species (ROS), DNA damage, tumor promotion, and arsenic exposure. This article summarizes the current literature on the arsenic mediated generation of ROS and reactive nitrogen species (RNS) in various biological systems. This article also discusses the role of ROS and RNS in arsenic-induced DNA damage and activation of oxidative sensitive gene expression.
Keywords
Arsenic-compounds; Disease-incidence; Disease-transmission; Cell-damage; Tumors; Genetic-factors; Free-radicals; Oxidative-processes; Carcinogenesis
Contact
College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
CODEN
MCBIB8
CAS No.
7440-38-2
Publication Date
20040101
Document Type
Journal Article
Email Address
jliu@unm.edu
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0300-8177
NIOSH Division
HELD
Source Name
Molecular and Cellular Biochemistry
State
NM; WV
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