Role of nitric oxide in the progression of pneumoconiosis.
Biochemistry (Moscow) 2004 Jan; 69(1):32-37
Conflicting evidence has been reported as to whether nitric oxide (NO) possesses anti-inflammatory or inflammatory properties. Data are presented indicating that in vitro or in vivo exposure to selected occupational dusts, i.e., crystalline silica, organic dust contaminated with endotoxin, or asbestos, results in upregulation of inducible ntric oxide synthase (iNOS) and the production of NO by alveolar macrophages and pulmonary epitelial cells. Nitric oxide production is assocated temporarilly and anatomically with pulmonary damange, inflammation, and disease progression in response to occupational dusts. Blockage of inducible ntric oxide synthase by administration of NOS inhibitors or in iNOS knockout mice decreases the magnitude of injury and inflammation following in vivo exposure to silica, endotoxin, or asbestos. Therefore, NO may play an important role in the initiation and progression of pneumoconiosis.
Pneumoconiosis; Nitrogen-compounds; In-vitro-study; In-vivo-study; Occupational-exposure; Dust-exposure; Silica-dusts; Endotoxins; Asbestos-dust
V. Castranova, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA