Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Signaling by carcinogenic metals and metal-induced reactive oxygen species.

Authors
Harris-GK; Shi-X
Source
Mutat Res 2003 Dec; 533(1-2):183-200
NIOSHTIC No.
20023933
Abstract
Epidemiological data indicate that exposure to metal and metalloid species, including arsenic(III), chromium(VI), and nickel(II), increases the risk of cancer, particularly of the lung and skin. Alterations in normal signal transduction as a result of exposure to carcinogenic metals, and to metal-catalyzed reactive oxygen species (ROS) formation, appear to play an important role in the etiology of metal-induced carcinogenesis. Signaling components affected by metals include growth factor receptors, G-proteins, MAP kinases, and nuclear transcription factors. This article reviews current literature on the effects of carcinogenic metals and metal-induced ROS on cancer-related signaling pathways. In addition, the mechanisms by which those changes occur, and the role of those changes in carcinogenesis are discussed.
Keywords
Metals; Heavy-metals; Carcinogens; Respiratory-system-disorders; Respiratory-neoplasms; Lung-cancer; Pulmonary-system-disorders; Pulmonary-cancer; Skin-cancer; Skin-disorders
Contact
National Research Council Associate, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Rd. (M/S 2015), 26505-2888, Morgantown, WV, USA
CODEN
MUREAV
CAS No.
7440-47-3; 7440-38-2; 7440-02-0; 7440-41-7; 7440-43-9; 7440-48-4; 7439-92-1; 7440-36-0; 7439-89-6
Publication Date
20031210
Document Type
Journal Article
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Issue of Publication
1-2
ISSN
0027-5107
NIOSH Division
HELD
Source Name
Mutation Research
State
WV
TOP