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Biological monitoring for exposure to coal tar.

Authors
Santella-RM
Source
NIOSH 1993 Jun
Link
NIOSHTIC No.
20023853
Abstract
A major goal of biological monitoring for exposure to genotoxic agents is to identify occupations as well as individuals at elevated risk for cancer development. Methods for the detection of carcinogen-DNA and protein adducts have been established. These methods require the collection of blood or tissue samples and are not practical for routine occupational monitoring. In this proposal, methods have been developed for the determination of exposure to benzo(a)pyrene (BP) by measurement of BP and its metabolites in urine. Since urine is much more readily collected than blood, this method should simplify workplace screening.
Keywords
Biological-monitoring; Coal-tar; Occupational-exposure; Risk-analysis; Risk-factors; Cancer; Genotoxic-effects; Carcinogens; Blood-samples; Benzopyrenes; Workplace-monitoring
Contact
Regina M. Santella, Columbia University, Division of Environmental Science, 650 West 168th Street, New York, NY 10032
CAS No.
50-32-8
Publication Date
19930601
Document Type
Final Grant Report
Funding Amount
651727
Funding Type
Grant
Fiscal Year
1993
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002622
NIOSH Division
OEP
Source Name
National Institute for Occupational Safety and Health
State
NY
Performing Organization
Columbia University, Division of Environmental Science, New York, New York
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